This paper calls upon health service providers, nongovernmental organizations, laymen, and farm laborers to help reduce the burden of disease in migrant and seasonal farm workers through appropriate effective preventive interventions. An individual's health care status does not exist in a vacuum. There are many factors that contribute to good and bad health. The opportunities for well being and equity in health are hindered by factors, such as poverty, hazardous working conditions, and unsanitary living conditions. In marginalized communities, access to and quality of curative and preventive health facilities also affect health. Qualitative and quantitative methods were employed in this research to capture migrant and seasonal farm workers' quality of health and to plan for interventions with the migrant and seasonal farm worker community. Qualitative methods included participant-observation and in-depth interviews. Quantitative methods included statistical findings. Data on communicable disease, including human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) are presented to show the level of sexually transmitted disease (STD) in a three county catchment area in rural North Carolina. The findings indicate a need to incorporate migrant and seasonal farm workers' perceptions within the planning cycle of health intervention programs.